Dr Sette is a leader in the field of T cell epitope-MHC interactions, beginning with his contribution to the discovery of the biological function of MHC in the mid 80s to mid 90s. From those studies he and his collaborators further developed the notion that different MHCs have distinct binding specificities that can be used to predict epitopes. The Sette group also discovered and characterized how MHC variants can be grouped according to broad common functional specificities (MHC supertypes), greatly facilitating epitope classification, characterization and understanding the basic rules of epitope-MHC interactions. At the same time, several studies have outlined the fine specificity of different closely related alleles, in some cases clearly associated with predisposition to disease resistance or susceptibility.
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