Prof. Adrian Martineau and Dr. Arne Soraas discuss vitamin D supplementation in the general population for prevention of COVID-19, based upon their randomised CORONA-VIT and CLOC studies, which have been published back-to-back in British Medical Journal in September 2022.
Adrian Martineau is Professor of Respiratory Infection and Immunity at Queen Mary University of London and Chief Investigator of the COVIDENCE UK study, into which the randomized CORONA-VIT study was embedded.
Arne Sorass is MD and PhD in the Department of Molecular Microbiology of Oslo University Hospital. As specialist in infectious diseases, he is Chief Investigator in the Norwegian Corona Cohort which follows 200.000 Norwegians through the pandemic, into which the CLOC study was embedded.
The interview was recorded on September 27th, 2022. Moderators: Prof. Dr. Martina Sester (Homburg, Germany) and Prof. Dr. Gunnar Heine (Frankfurt / Homburg, Germany).
Articles discussed:
Comparative immunogenicity and reactogenicity of heterologous ChAdOx1-nCoV-19-priming and BNT162b2 or mRNA-1273-boosting with homologous COVID-19 vaccine regimens.
Klemis V, … , Sester M.
Nat Commun. 2022 doi: 10.1038/s41467-022-32321-0
Efficacy and Safety of Vitamin D Supplementation to Prevent
COVID-19 in Frontline Healthcare Workers. A Randomized
Clinical Trial.
Villasis-Keever MA, López-Alarcón MG, Miranda-Novales G, et
al.
Arch Med Res 2022 doi:10.1016/j.arcmed.2022.04.003
Immunogenicity and reactogenicity of heterologous ChAdOx1 nCoV-19/mRNA vaccination.
Schmidt T, …., Sester M.
Nat Med. 2021 doi: 10.1038/s41591-021-01464-w
Vitamin D and tuberculosis: where next?
Brighenti S, Bergman P, Martineau AR.
J Intern Med. 2018 doi: 10.1111/joim.12777
Vitamin D Supplementation Does Not Influence SARS-CoV-2 Vaccine Efficacy or Immunogenicity: Sub-Studies Nested within the CORONAVIT Randomised Controlled Trial.
Jolliffe DA, Vivaldi G, Chambers ES, Cai W, Li W, Faustini SE, Gibbons JM, Pade C, Coussens AK, Richter AG, McKnight Á, Martineau AR.
Nutrients. 2022 doi: 10.3390/nu14183821
Do not routinely test for vitamin D.
McChesney C, Singer A, Duquette D, Forouhi NG, Levinson W.
BMJ. 2022 doi: 10.1136/bmj-2022-070270
Prevention of covid-19 and other acute respiratory infections with cod liver oil supplementation, a low dose vitamin D supplement: quadruple blinded, randomised placebo controlled trial
Brunvoll S H, … Søraas A.
BMJ 2022 doi:10.1136/bmj-2022-071245
Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT)
Jolliffe D A, …., Martineau AR.
BMJ 2022 doi:10.1136/bmj-2022-071230
Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data.
Martineau AR et al.
BMJ. 2017 doi: 10.1136/bmj.i6583.
Vitamin D Supplements for Prevention of Tuberculosis Infection and Disease.
Ganmaa D, …., Martineau AR.
N Engl J Med. 2020 doi: 10.1056/NEJMoa1915176.
Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials.
Jolliffe DA…., Martineau AR.
Lancet Diabetes Endocrinol. 2021 doi: 10.1016/S2213-8587(21)00051-6.
