New research finds repeated boosters may pivot IgG antibodies to more non-protective subclasses.
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0:00 Intro
Hey friends welcome back so we’re going to talk about two recently published studies and this might in fact be one of the most important videos we made about kova 19 up to now we’re going to talk about a recently published study that found that repeated immunizations from the MRNA vaccines actually pivot your
Adaptive immune system to make non-neutralizing antibodies remember how important we heard Health officials and pundits say the reason why you need boosters is to get your antibodies as high as possible well it turns out that there’s four different subtypes of your IGG antibodies the first three are protective the last one is not
Neutralizing the last one is saying hey look we’ve seen this antigen I.E the spike protein or in the case of beekeepers this the state of IGG subclass switching has been talked a lot about in in people who who keep bees and they’re constantly stung by bees and so
The immune system says look we’re going to see this antigen all the time so what we’re going to do is instead of making these protective IGG antibodies what we’re going to we’re going to Pivot the immune system to make non-neutralizing antibodies because you see it so much it
Probably doesn’t matter right and so what this study showed in healthcare workers is there was a linear increase in the number of immunizations linked with a percentage of the IGG antibodies that switched to this non-neutralizing igg4 antibody which this is damning this should really cause us to rethink our
Health campaign especially for young people who are going to see covid for the rest of their life this is never going away so if repeated exposure to the spike protein by way of minimization or just natural infection causes this class switching which might make a repeat infection more severe then what
We should be doing is promoting health and really backing off especially in applying risk stratification when it comes to repeated booster shots and immunizations as you can see here in figure two they show that there is a dramatic switch from neutralizing antibodies to this non-neutralizing igg4
Subclass you can see here and what they show is that there was no detectable levels of igg4 non-neutralizing antibodies before a vaccination but they increased linearly and iteratively with every successive mRNA vaccine and the authors say we detected spike-specific igg4 antibodies and about half of serum samples collected from five to seven
Months after the second immunization all of which did not show any igd4 antibody subtypes at earlier time points for all IGG subclasses a decline was seen in the same period now this paper helps sort of characterize the declining efficacy that we’ve been seeing and this is now
Washington Post has reported on this New York Times has reported on this Wall Street Journal major media Outlets have said well why are there was so much hype and so much promise and so much enthusiasm for the vaccines but now we’re seeing they’re not working as well
As we thought even after people have been getting multiple of these mechanistically what’s going on this paper highlights potential mechanisms here and that is when you repeatedly show the human immune system the same antigen over and over and over again there is some sort of protective mechanism where the types of IGG
Antibodies pivot away from protective neutralizing antibodies to this more non-neutralizing igg4 subclass which might be why some people are getting sicker after a reinfection particularly if they’ve had multiple immunizations not the adenovirus vector immunizations it’s important to recognize here the study was looking specifically at the MRNA vaccines so they conclude and say
Moreover after the third immunizations igg4 levels sharply increased and became detectable in almost all vaccinees now remember igg4 is a subclass of IGG antibodies that is non-neutralizing this paper should be front page news and should really influence public health policy makers and companies I mean companies are complicit here I know
Employees at Facebook and Amazon and major tech companies and so forth even teachers they are requiring even Volunteers in classrooms or summer camps believe it or not literally I was looking at a summer camp for my daughter and there was a little subtext here your
Child must be up to date on all of the kova 19 vaccinations so we know that about 90 of kids or 95 percent of kids have antibodies to the nuclear capsid which is one antigen on Stars CO2 why are we making kids when they already have adaptive immunity by the way why
Are we making them have more immunizations my friends this makes no sense as I said from the very beginning we need to focus on health exercise nutrition stress reduction circadian rhythm optimization sleep having meaning purpose like friends in your life these are things that actually improve immune
Health we’ve ignored that and now we’re trying to play catch-up and I don’t think there is ketchup I don’t think there is a solution outside of going back to the basic 6 and this could include incentivizing Health instead of subsidizing corn and canola oil and sugar why don’t we subsidize gems why
Aren’t we subsidizing healthy food these are the policy level decisions that we could and should be making if we’re serious about saving lives my friend so this is really important but before we go on friends I just want to thank you for being here you know when we talk
About these content the algorithms don’t really like it so we depend on you to share this content to hit that like button to text this to a friend so that they get access to this information also friends we’re trying to inspire Health on this platform we’re not that’s our
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The code podcast on a range of Health tools including t-shirts to have these meaningful conversations so let’s talk about the recently published study that found that individuals who got reinfected with covid have increased risk of death and all-cause mortality and severe sequela associated with that reinfection but I think there’s some
Limitations of this study and this was trending on Twitter all weekend and many people are saying see if you get covered the second time or a third time that means that you’re more likely to die and suffer from all these problems so therefore we should reinstitute mandates now the important conclusion that I
Think these people are not thinking about is how are you going to do that how are you going to prevent covert from stopping how are you actually going to prevent getting infected with covid because many people have had one two three four five vaccinations up to now they’re still getting breakthrough
Infections which is why that second study is really important that we’re going to talk about today but more importantly during the point in which we had all these mandates mask mandates and school closures and restrictions guess what we saw the highest level of cases in the US and I’m talking about December
Of 2021 and January of 2022. go back and look at the statistics I mean in the state of New York for example in Manhattan if you want to go to a bar not only did you need to show proof of immunization not not only did you need
To also wear a mask but some bars and restaurants required a negative covid-19 test okay that is insane that’s ridiculous how much more extreme could we actually get and if we look no further than the country of China who tried myopically to attempt this zero coveted strategy well they just said
Forget about it like we cannot control this virus it’s endemic we should then now as you know we’ve talked a lot about focus on health and that’s why this study here published in nature medicine titled acute and post-acute sequela associated with SARS CO2 reinfection now
At first you think oh my gosh this study is frightening because these people who got reinfected with covid after a primary infection well they had all these health problems they had increased risk of dying and and all the like and there was you know five million people
As part of the study but what you don’t really recognize is the the population that is being studied here are veterans part of the VA now I have several friends who are Physicians that work for the VA and they’ll be the first to tell me that many of the patients they see
Have a lot of underlying health issues so this is a unique subset of the population so what people are doing on Twitter is they see this paper and they see oh my gosh the hazard ratios have increased all-cause mortality death and heart disease as a result of getting
Covet again is much higher so therefore they conclude we need to re-implement restrictions in masking and get our kids out of school again that doesn’t work that’s not sustainable this is not going away and so that’s what I want to share with you a major limiting factor of the
Study that is going viral is only 12 percent of the study subjects were under 38 years old meaning that 90 of the people were over 40. now that doesn’t represent the entire American population your children are going to get coveted over and over and over again so that
Means that you and your children should be eating healthier foods should be exercising should be doing all the things to improve improve immune health and to decrease the underlying health conditions that are very pervasive in this population that is getting coveted again that’s major important major Point number one major Point number two
Is this sentence right here this is what the authors say they say the risks were evident of increased all-cause mortality cardiovascular disease related mortality and health challenges as a result of the reinfection regardless of vaccination status they said the risks were the most pronounced in the acute phase but also
Persisted in the post-acute phase six months after reinfection okay let’s just talk about that again they said the risks of all these health issues after reinfection were independent of one’s vaccination status which may makes us really Ponder in question then where are we going with our current vaccination
Policy if the vaccines don’t prevent the transmission of the virus as as the authors say in nature medicine this isn’t some conspiracy Journal they say the risk of increased all-cause mortality and carvascular mortality and and complications associated with a re-infection are just as high for people
Who have had the vaccine compared to the people that haven’t then why are we still recommending the vaccines why are we Reckoning boosters especially in light of this new paper we’re about to talk about about IGG subclass switching which is just crazy so they go on to say compared to non-infected controls
Cumulative risks and burdens of repeat infection increase according to the number of infections limitations including a cohort of mostly white males and so they say the evidence shows that reinfection further increases risk of death hospitalization and sequela in multiple organ systems in the acute and post-acute phase and they say reducing
Overall burden of death and disease due to SARS scope 2 will require strategies for reinfection prevention okay how are you going to do that we’ve all been masked people stay in their houses we can no longer continue to do that we’ve seen the iatrogenesis linked with that
From inflation to supply chain issues to kids not learning as much in school to obesity depression drug overdoses so how are we going to actually prevent a reinfection here’s an alternative way to view this this new data that does show and I’m not saying go out there and get
Coveted every week okay by the way and that’s physiologically not possible as we’ve talked about before a new study from Qatar are compared natural media compared to vaccine induced immunity and found actually greater rates of preventing a reinfection so immune systems work and you can improve your ability to prevent a reinfection by
Increasing your health with exercise nutrition stress reduction sleeps or kidney Rhythm optimization vitamin D all the things that we should have been promoting in early part of 2020 that we actually ignored so that’s how I interpret this this study but again many people on Twitter are sharing this
Figure one the title here is risk and burden of sequela and people with sarscope 2 reinfection versus no infection and they’re showing an increased risk of all-cause mortality increased risk of hospitalization and increased risk of cardiovascular disease and diabetes in these things okay the important thing to remember my friends
Is this population is probably already sick to begin with and an older population so yeah you don’t want to get coveted all the time but yeah if we improve our underlying health conditions I bet this risk would absolutely go away and again to prevent the risk of a symptomatic reinfection you you can
Decrease that by improving your health and your lifestyle and so the thing that I think is important about this study is not to be alarmed by this but to take an offensive approach in terms of preventing a symptomatic reinfection by improving your life don’t overwork don’t under exercise don’t eat Ultra processed
Foods do all the things that have been shown to prevent an infection in the first place we’ve shared with you many studies over the past two years that show that people who exercise compared to people who don’t are less likely to test positive for cover 19. we’ve shared
Studies about body fat percentage people with lower body fat percentage have a lower viral load was this study looking at body fat percentage and stratifying people in different cohorts but what’s I think most important about this study and this hints at where we’re going is they did not enumerate or quantify and
Look at the different cohorts of people who were vaccinated versus unvaccinated I think that’s most important I would love to know in this study parsing out the cohorts of people who had severe re-infection if they were vaccinated before or unvaccinated and thanks for watching all the way through hopefully
You found this video helpful and the associated article is helpful as well I will also include an article here about what igg4 antibodies are and how they’ve been studied for the past 20 years and and are really quite pronounced in beekeepers and people again that are exposed continually to
Venom from from bees bee stings and things like that so there’s a lot known about these antibodies and it seems that the body’s the body is so intelligent this complex system we cannot play God anymore your body knows what it’s doing through years millions of years of
Evolution and it seems that again when the body knows it’s being constantly bombarded by the same antigen instead of increasing protective antibodies that neutralize it it’s making non-neutralizing antibodies which might make the infection worse or reinfection worse and so that remains to be determined but time will tell so as
Always appreciate tuning in thanks for hitting the like button thanks for sharing we’ll catch you on the future one down the road bye
