Image:
Caption:
Jutta Jalkanen.
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“The next step is to understand the role of fat tissue around the colon in inflammatory bowel diseases such as Crohn’s and ulcerative colitis. Now that we know it contains both fat cells and immune cells, we want to investigate how their interaction influences disease activity. Our goal is to find out whether this fat tissue contributes to amplifying or sustaining inflammation by sending signals that affect immune cells locally,” says Jutta Jalkanen, researcher at the same department and co-first author of the study.
The study was funded by, among others, the Swedish Research Council, the Novo Nordisk Foundation, ERC, and the Knut and Alice Wallenberg Foundation. Some researchers have received fees from pharmaceutical companies, as disclosed in the scientific article.
Publication
“Cytoarchitectural multi-depot profiling reveals immune-metabolic crosstalk in human colon-associated adipose tissue”, Jutta Jalkanen, Jiawei Zhong, Pamela A. Nono Nankam, Nayanika Bhalla, Merve Elmastas, Jiaxin Luo, Sophie Weinbrenner, Scott Frendo-Cumbo, Benedek Pesti, William Gourash, Anita Courcoulas, Zinger Yang Loureiro, Arne Dietrich, Jesper Bäckdahl, Anders Thorell, Marcus Buggert, Joanna Kalucka, Margo P. Emont, Evan D. Rosen, Matthias Blüher, Peter Kovacs, Patrik L. Ståhl, Lucas Massier, Mikael Rydén and Niklas Mejhert, Cell Metabolism, online 13 January 2026, doi: 10.1016/j.cmet.2025.12.008.
