Is LERONLIMAB A Game Changer? Coronavirus (COVID-19) Treatment | How does LERONLIMAB Work? | RANTES and CCR5 Blocking
Leronlimab is a humanized monoclonal IgG antibody and a potential medication and treatment against coronavirus (COVID-19) infections. Leronlimab was originally developed for HIV and works by blocking the CCR5 receptor and stopping the calcium signaling. The CCR5 receptor is a known receptor for many inflammatory chemokines including CCL5, also known as RANTES.
RANTES stands for “regulated on activation, normal T-Cell expressed and secreted” and is a chemokine produced by t-lymphocytes, basophils and macrophages. The RANTES chemokine is expressed by many immune cells and plays a role in homing and migration of T cells during acute infections.
By blocking the CCR5 receptor on leukocytes, the idea with leronlimab to treat coronavirus is you block the transmission of the chemokine signal from RANTES, thus preventing the migration of more immune cells to attenuate a cytokine storm.
It is also believed that leronlimab’s other effect is polarization of macrophages from pro-inflammatory to antinflammatory phenotypes.
CCR5 is a chemokine receptor and is expressed by T-cells and macrophages and is known to be an important co-receptor, along with CD4, of HIV. The CCR5 gene is located on chromosome 3 at position 21 and a 32 base pair deletion in the gene is associated with HIV infection resistance. Therefore research has been focused on CCR5 blocking and gene editing knockout of the receptor to treat many diseases and infections.
Highlights from a press release from Cytodyn reporting Leronlimab’s effectiveness against coronavirus (COVID-19):
1. Complete inhibition of IL-6 by day 14 and significant reduction by day 7
2. Restoration of CD8 and CD4 counts to normal with normalization CD4/CD8 ratios
3. Decrease in t-regulatory cells that inhibit innate and adaptive immunity
4. Reduction in plasma viral load
5. And in over 800 patients studied in HIV trials, there were no serious adverse effects observed with the use of leronlimab.
-Watch the video to get more information about why leronlimab is a potential game changer against the fight with COVID-19
-Dr. Yogendra
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