Stress is considered a silent killer, but more specifically, it is oxidative stress in our cells that’s linked to disease, decline, and health issues. The good news is that the best glutathione supplements can help. “Think of glutathione as your body’s natural protector,” explains Nayan Patel, MD, an advanced biochemistry and anti-aging science expert and the founder of wellness brand Auro. “It helps maintain balance at the cellular level by protecting against daily stressors, reviving other antioxidants like vitamins C and E, and supporting the body’s built-in detox pathways—starting with the liver.”
Glutathione is a highly specialized tripeptide and most powerful antioxidant in the body. “What makes glutathione unique is that it works inside the cell, where most oxidative stress actually happens,” says board-certified family medicine physician Heraa Chaudhry, MD. “Many antioxidants circulate in the bloodstream, but glutathione functions within cells to help neutralize free radicals at their source.”
Vogue’s Favorite Glutathione Supplements:Best For Antioxidant Support
Cymbiotika Liposomal Glutathione
Jump to reviewBest with Milk Thistle
Now Foods Solutions Glutathione 500 mg
Our bodies naturally produce glutathione, and optimal levels can be maintained through diet and lifestyle factors. “Sulfur-rich foods like broccoli, brussels sprouts, garlic, and onions, along with adequate protein, regular exercise, and quality sleep, are foundational for adequate glutathione levels,” says Chaudhry. However, pretty much every facet of modern-day life can contribute to draining our glutathione levels. “Aging, chronic stress, environmental exposure, poor sleep, and illness can all deplete levels over time,” says Patel. “Since oxidative stress is linked to nearly every known disease process, glutathione serves as the body’s primary natural protector, helping maintain balance at the cellular level.”
If you’re interested in this magic antioxidant, we asked leading experts to weigh in on the latest innovations, ingredients to prioritize, and how to evaluate the best glutathione supplements on the market.
AccordionItemContainerButtonBest Glutathione Supplement Overall: Pure Encapsulations Liposomal Glutathione
Pure Encapsulations
Liposomal Glutathione
Why We Love It: One of the reasons many professionals love Pure Encapsulations is for its premium-grade quality, transparency, and efficacy. This formula in particular offers a liposomal delivery—a 125 mg phospholipid complex—to protect against degradation during digestion. It also includes a clinically studied glutathione called Setria L-Glutathione, revered for its purity, quality, and powerful results. Pure Encapsulations also takes transparency a bit further: While it lists its proprietary glutathione complex BioGlute on the ingredient label, it breaks down exactly what is in it—250 mg of Setria l-glutathione and 125 mg of a phospholipid complex—for total clarity.Key Ingredients: Setria glutathione, phospholipid complexDose: 1 soft gelForm: Soft gelSize: 30 soft gelsBest Glutathione Supplement for Antioxidant Support: Cymbiotika Liposomal Glutathione
Cymbiotika
Liposomal Glutathione
Why We Love It: One of these gel sachets a day delivers a dose of reduced glutathione in a citrus-vanilla flavor, making it incredibly convenient (and pleasant) to take regularly. It’s perfect for busy days while you’re on the go or stashing in your travel bag. “Maximizing the benefits of glutathione comes down to thoughtful formulation, consistency, and pairing supplementation with supportive lifestyle habits such as proper nutrition, hydration, and restorative sleep,” says Chaudhry. Made with other powerful antioxidants—CoQ10 and PQQ—for additional cellular support, as well as vitamin B12, this squeezable gel gives added antioxidant support for a comprehensive approach.Key Ingredients: Reduced glutathione, PQQ, vitamin B12Dose: 1 packetForm: GelSize: 26 packetsBest Reduced Glutathione Supplement: BodyBio Liposomal Glutathione
BodyBio
Liposomal Glutathione
Why We Love It: Glutathione exists in two different states within cells: oxidized (GSSG) and reduced (GSH). GSH has active antioxidant properties that act as scavengers for free radicals and plays a major role in the removal of toxins. Oxidized glutathione (GSSG) is essentially the inactive form that arises when GSH has neutralized toxins. Research shows that oral glutathione supplementation was effective in elevating reserve levels of GSH in the body, which impacted immune function and levels of oxidative stress. Third-party tested and manufactured in a cGMP-certified facility, this capsule not only includes reduced glutathione for optimal effectiveness, it comes in a liposomal form to ensure you can actually reap the benefits of taking it.Key Ingredients: Reduced glutathione, sunflower-derived phospholipidsDose: 1 capsuleForm: CapsuleSize: 60 capsulesBest Liposomal Glutathione Supplement: Codeage Liposomal Glutathione
Codeage
Liposomal Glutathione
Why We Love It: Glutathione encapsulated in liposomes (lipids that protect from stomach acids) help it move through the body more effectively so it reaches the intestinal tract intact, to help enhance absorption and bioavailability. “Liposomal glutathione may offer improved bioavailability compared to standard capsules due to its fat-based delivery system,” says Chaudhry. This capsule delivers 500 mg of high-potency, clinically tested Setria L-glutathione in an encapsulated powder-pill form using a liposomal phospholipid complex sourced from non-GMO sunflower. It’s vegan, non-GMO, dairy-free, soy-free, and gluten-free, making it a top choice for those with a variety of dietary restrictions.Key Ingredients: Setria L-glutathioneDose: 2 capsulesForm: CapsuleSize: 60 capsulesBest Glutathione Supplement With Milk Thistle: NOW Foods Glutathione
Now Foods Solutions
Glutathione 500 mg
Why We Love It: Not only is this glutathione supplement affordable, readily available at your local health store, and made with high-quality ingredients, it’s made with milk thistle extract to supercharge your glutathione levels. The active component in milk thistle seeds, silymarin, has been shown in some studies to increase glutathione levels naturally up to 35% to 50% by protecting liver cells and supporting their function. “Glutathione plays a central role in the liver’s natural detoxification processes, helping the body naturally process and clear metabolic byproducts,” says Dr. Chaudhry. “It helps protect cells from everyday exposures—environmental toxins, pollution, metabolic byproducts, and inflammatory stressors—to maintain internal balance.”Key Ingredients: Glutathione, milk thistle extract, alpha lipoic acidDose: 1 capsuleForm: CapsuleSize: 30 capsulesBest Liquid Glutathione Supplement: Quicksilver Scientific Liposomal Glutathione
Quicksilver Scientific
Liposomal Glutathione
Why We Love It: Those who prefer taking their supplements in liquid form to avoid swallowing pills will love that this comes in two refreshing flavors—lemon mint and cacao mint. There’s a few different delivery systems for glutathione, but according to Chaudhry, “oral supplementation is convenient but absorption can vary due to breakdown in the digestive tract.” That’s where liposomal formats may help. “Liposomal formulations are designed to improve stability and bioavailability,” she adds. This liquid encapsulates the power of glutathione in teeny-tiny nano liposomes—less than 100 nm—which the brand says is even more easily absorbed by your body. A daily dose is two pumps by mouth, followed by holding the liquid in your mouth for 30 to 90 seconds before swallowing. By using this sublingual method, some research suggests it could potentially support more rapid absorption of the nutrient through mucosal tissues and bypass digestion.Key Ingredients: Opitac glutathione, phosphatidylcholineDose: 1 mL (2 pumps)Form: LiquidSize: 1.7 ozBest Low-Dose Glutathione Supplement: Renue by Science Lipo Glutathione
Renue by Science
Lipo Glutathione
Why We Love It: Regularity is super important when it comes to supplementing with glutathione, and one of these liposomal vegetarian capsules delivers a low 130 mg dose that’s ideal for beginners to help bolster glutathione levels. Most clinical studies show benefits with 250 to 500 mg of glutathione per day. If you’re new to glutathione, it’s most important to do so under medical guidance. “Physician-guided supplementation may be considered to support the body’s antioxidant defenses but dosages and administration should be tailored to an individual’s health history and goals,” says Dr. Chaudhry. “Ultimately, maximizing benefits comes down to thoughtful formulation, consistency, and pairing supplementation with supportive lifestyle habits.”Key Ingredients: Glutathione, sunflower lecithinDose: 1 capsuleForm: CapsuleSize: 90 capsules
