Registered dietitian Sahar Berjis and other experts weigh in on the supplements that help address the nutrition gap and other side effects from weight loss medications
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As GLP-1 treatments become more mainstream and accessible, gyms, fast food companies and other fitness and wellness brands are offering programs and products to support those using weight loss drugs.
However, experts note that weight-loss journeys isn’t just about taking a shot or pill: GLP-1 users should also work to “protect muscle and build metabolic resilience” to make their treatments more effective, says Sahar Berjis, RD, founder of Southern California-based Inner Health and Wellness, which offers customized meal programs based on clients’ genetic and physical states.
Some of the best supplements for people using GLP-1s help address side effects such as nausea and constipation, the decrease in muscle and bone density caused by rapid weight loss and nutrient gaps due to reduced calorie intake. Lifesum lead nutritionist Signe Svanfeldt previously told ATN that taking protein can help maintain and build muscle mass, which in turn helps the body’s capacity to burn calories while resting. “This is particularly crucial during weight loss, where the objective is to lose fat while preserving muscle,” she explains.
Related: The Best Protein Drinks, Mixes and Powders for Powering Your Routine
Berjis tells Athletech News that she recommends getting a blood test “before adding supplements or committing long-term. I encourage baseline blood work to understand what’s happening under the hood, especially with gut and insulin health. We also rely on micronutrient testing to get a forward-looking analysis of vitamin and mineral deficiencies — something that’s especially important for people using GLP-1s, where eating less can quietly mean absorbing less.”
One of the biggest misconceptions that Berjis hears when it comes to using GLP-1s? The registered dietician and nutritionist says many people often think, “‘I don’t need to worry about food or exercise anymore.’ If only. Skipping those basics makes it much harder to come off the medication – or to push past the inevitable plateau once the drug stops doing the heavy lifting. GLP-1s can quiet appetite, but they don’t magically protect muscle or build metabolic resilience. That’s why I emphasize higher protein intake to support lean mass and often recommend Akkermansia to help strengthen gut flora and insulin response.”
Supplement and biomarker testing brands are also addressing customers’ concerns about weight loss programs through AI advisors.
Thorne recently launched Taia, an AI Wellness Advisor that can answer questions such as “what supplements should I take while on a GLP-1?” The supplements company offers a range of products, such as fiber to support gut health, magnesium for healthy bowel movements, creatine and protein to maintain lean muscle mass, vitamin D and other multivitamins to address nutrition gaps due to reduced appetite and berberine to support healthy blood sugar metabolism (especially for those diagnosed with pre-diabetes).
Meanwhile, biomarker testing company Superpower‘s AI-powered Concierge takes your lab test results and metabolic history into account when recommending supplements such as vitamin D, protein and amino acids, magnesium glycinate and other products.
“Not long ago, many of my clients were talking about bariatric surgery. These days? I’ve seen a huge shift in both interest and conversation around GLP-1 medications,” adds Berjis. “Same destination – weight loss and better metabolic health – but now we’re using a very different GPS… and occasionally missing a few turns along the way.”
For those who prefer to work with a human, Berjis explains that her InnerHealthWellness app can offer the best of both worlds. “Because real life happens between appointments, we use the InnerHealthWellness app to fill in the gaps – offering guidance, habit tracking, and real-time support so clients aren’t left guessing,” she says. “
It’s worth noting that many supplements with “GLP-1” in the product name aren’t substitutes for prescription drugs. PBS reports the rising number of supplements that claim to “boost” GLP-1 production when taken with medication or purport to be “‘natural’ versions of GLP-1 agonists that may work but be substantially less effective.”
elehealth platforms such as Serena Williams-backed and others offer online GLP-1 prescriptions for semaglutide (Ozempic and Wegovy) and tirzepatide (Zepbound and Mounjaro) to support weight loss, glucose control and other health concerns.
Whether you’re using a GLP-1 prescribed by your primary care physician, or going through a telehealth platform such as Noom, Ro, Hims & Hers, Nurx, we’re rounding up supplements to consider taking based on expert advice from the registered dietitians and nutritionists we interviewed. See our top picks below, and be sure to consult with your primary care physician to make sure these supplements fit your health needs.
The Best Supplements for GLP-1 Users in 2026
Best bundle overall
GLP-1s suppress your appetite, resulting in reduced calorie intake. Thorne’s GLP-1 Support Stack bundle includes Daily Electrolytes, Amino Complex, Complete Biotic and Basic Nutrients, which work together to fill nutrient gaps from decreased eating and support indigestion and bowel issues, muscle and bone strength and cellular hydration. The company says this stack is ideal for those on a GLP-1, including people with type 2 diabetes.
Best customizable bundles
$129.98 ($420), 69% off first order
Pendulum offers probiotic and supplement bundles for gut support, metabolic health and glucose regulation, depending on your needs. As Berjis explained, Akkermansia helps strengthen the gut lining and improve digestive health, while Pendulum recommends pairing it with their Polyphenol Booster to boost Akkermansia’s results. Not sure where to start? The company’s online quiz can guide you in the best direction.
Best vitamins
Concerned about nutrient gaps while using a GLP-1? NatureMade’s GLP-1 Companion Health Pack is specifically formulated for those on a weight loss medication. It contains magnesium, B12, calcium, D3 and more vitamins and minerals to for supporting muscle and bone strength, cellular energy production, immune health and metabolism.
Best GLP-1 fiber mix
Supergut’s GLP-1 Daily Support contains four fibers that work together to support metabolic health, appetite control and digestion, and can be mixed into your coffee, yogurt, smoothies, shakes and other drinks. Solnul is “linked to satiety and metabolic signaling,” oat beta glucan for for healthy blood sugar and heart health, sulobule vegetable fiber for digestion and green banana fiber “with powerful prebiotic benefits.”
The non-GMO formula is glyphyosate- and gluten-free’ vegan; suitable for low FODMAP diets; and is third-party tested.
Best fiber supplement overall
Thorne’s soluble prebiotic fiber “helps maintain healthy blood sugar levels, promotes regularity and supports optimal digestive function,” and helps to keep you feeling fuller, longer, per the brand. It’s dairy-, soy- and gluten-free, and contains Sunfiber, guar gum, larch arabinogalactan and gree tea phytosome.
Best budget-friendly bundle
Replenza’s GLP-1 Support bundle contains 22 vitamins and minerals, electrolytes, enzymes, collagen, probiotics and more to support digestive health, muscle recovery and skin elasticity during your weight loss journey.
Best creatine overall
Momentous’ bestselling Creatine contains 5g per serving for supporting lean muscle growth, cellular energy and mental clarity.
Best creatine gummies for women
Our favorite creatine in gummy form, Arrae’s Tone gummies come in delicious flavors are are specifically designed for women “because it helps with everything from buildng muscle to being able to recover faster, company founder Siff Haider says.
Best creatine for workouts
Supernatural instructor Leanne Pedante is a fan of Legion’s creatine gummies, and she notes that creatine “reliably boosts strength, can increase lean mass and is generally considered safe for healthy adults at standard daily doses. I can’t count on myself to remember to use the powder every day so the gummy format makes consistency effortless, and these actually taste good.”
Best protein shake
Huel’s Ready-to-Drink shake is packed with 20g of plant-based protein and 27 vitamins and minerals per bottle, and contains a balanced blend of carbs, fiber and fats – ideal for supporting weight loss from GLP-1s.
Best protein powder
Transparent Labs’ bestselling grass-fed whey protein isolate features 28g of protein and just 1g of sugar – and it comes in more than 20 yummy flavors, including chocolate milkshake, strawberry milkshake, mocha, s’mores, mint chocolate chip and more.
Best vegan protein powder
One of the best plant-based protein powders, 1st Phorm’s Vegan Power Pro contains 19g of protein per serving, amino acids and a blend of fruists and vegetables.
