COVID -19, Update, Friday 5th June Lancet Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis, (May 22nd)
Serious scientific questions about the validity of data
‘Expression of Concern’
Lead author, Prof Mandeep Mehra, (Brigham and Women’s Hospital, Boston)
asked Lancet for retraction
Richard Horton appalled, ‘This is a shocking example of research misconduct in the middle of a global health emergency’
Retraction reference
A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19 (3rd June)
Measles
Cambodia
Nepal
Ethiopia
Measles
Highly contagious, serious, viral
1963
Major epidemics every 2–3 years, an estimated 2.6 million deaths each year.
140 000 people died from measles in 2018
Mostly children under the age of 5 years
Passed through direct contact and through the air.
Infects the respiratory tract, then spreads throughout the body
2000 – 2018, measles vaccination prevented an estimated 23.2 million deaths.
Global measles deaths have decreased by 73% from an estimated 536 000 in 2000 to 142,000 in 2018.
Vaccines
Global vaccine summit
10 in human trials
Oxford group
AZ can make 2 billion doses
Moderna
Phase II clinical trial
Safety, reactogenicity and immunogenicity
Phase I, neutralising antibody titres at or above convalescent sera
Phase III trial in July
