Men, and especially male smokers, appear to be more likely to develop lung cancer if they take high doses of vitamins B6 and B12, new research suggests. For men taking these vitamin supplements, the risk of lung cancer was nearly doubled. For men who smoked, the risk was between three and four times higher. However, the study wasn’t designed to prove cause-and-effect between the vitamins and lung cancer; it only showed an association. It’s also not clear why only men and current male smokers seem to face an extra risk. The study found no sign of a link between folate and lung cancer risk. And vitamin B6 and B12 supplements didn’t seem to affect risk in women.

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