Robin J. Shattock, PhD, Faculty of Medicine, Department of Infectious Disease, Chair in Mucosal Infection and Immunity, Imperial College London, “Development of an saRNA vaccine against COVID-19”
Dr. Shattock presented an approach of a self amplifying RNA vaccine against COVID-19. It is based on a synthetic platform, which makes it comparably cheap, easy and fast to produce. Since the RNA itself is rather fragile, a multi-lipid complex for delivery was developed, which controllable releases the active compounds based on the surrounding pH level. The vaccine recently left the stage of toxicology testing on rats and just entered the stage of immunogenicity testing in non-human primates.
