Coronavirus vaccine latest update: Oxford vaccine for coronavirus found “SAFE” in early trials; triggers immune system response. – result published in Lancet Journal
COVID-19, the highly infectious novel coronavirus is spreading at a record rate globally as the number of positive coronavirus infections is inching closer to the 15 million mark as of 20 July. The world has put a determined front to contain the spread of the contagion which has caused more the 6 lakh fatalities worldwide. The good news amidst all the chaos is that out of the 155+ vaccine candidates in various stages of trials, 3 vaccines have reached the Phase III clinical trials.
Oxford’s Coronavirus vaccine candidate triggers immune response.
The much-awaited result of Phase I/II trials of the Oxford University’s vaccine candidate ‘AZD1222’ has just been released and it just might be the first piece of good news in 2020. The results have been published in the medical journal The Lancet. It has reinstated the earlier media reports which cited that Oxford’s vaccine candidate is fit for human use and develops protective immunity in the body of the volunteers.
As per the latest update, Richard Horton, the editor of the UK-based science journal ‘The Lancet’ noted that “the vaccine is safe, well-tolerated, and immunogenic.” He also underlined that the results were “extremely encouraging.”
How was Oxford’s Coronavirus vaccine developed?
The vaccine candidate was developed within 3 months by the Jenner Institute of the Oxford University and has been made using the genetic material of the spike protein of SARS-CoV-2 combined with weakened version adenovirus. Adenoviruses actually cause common cold in chimpanzees.
What is the Phase III human trial?
For the unversed, stage III of clinical trials (or human trials) is where medical experts and scientists dose thousands of volunteers with the vaccine candidate to understand if the vaccination provides active protection against the coronavirus. This is the final stage trial done just before getting approval from the regulatory authorities to launch the vaccine for mass-usage.
As of now, vaccine candidates developed by the University of Oxford, Chinese company Sinopharm and Chinese pharmaceutical giant Sinovac have reached the Phase III of human trials.
Promising Result of Oxford Vaccine’s Phase I trials released on The Lancet.
Touted as one of the frontrunners in the race to develop a vaccine fit for human use, Oxford University’s vaccine candidate has been in the news recently owing to various media reports, which claim that the potential vaccine has shown extremely promising results in its Phase I trials.
While the researchers and developers of the AstraZeneca-backed potential vaccine did not comment on the media reports doing rounds, the Lancet medical journal published the data of Phase I trial of Oxford and AstraZeneca’s COVID-19 vaccine candidate, AZD1222, today. The results were found to be “extremely promising” and the vaccine candidate has been deemed fit for human use.
Oxford vaccine can provide ‘double-protection’ against the coronavirus, says report.
The UK drugmaker AstraZeneca has been given the license to produce Oxford’s potential coronavirus vaccine. Additionally, there have been reports that the vaccine developed by Oxford’s Jenner Institute has shown extremely promising results in the development of ‘double protection’ against the virus. The reports maintain that the researchers at Oxford University are hopeful of the vaccine’s success as it is shown to trigger the production of both the protective antibodies and “Killer T-cells” in the body.
The development of T-cells in the volunteers by the AZD1222–which are known to last much longer in the human body after contracting the virus–comes as a sigh of relief. This is because recent studies have found that the protective antibodies produced in the survivors of COVID-19 started waning after just three months, which could prove to be a big roadblock in the development of a vaccine for coronavirus.
