Omicron – Is Immune Escape Imminent? A Deep Dive
Concern over the Omicron’s unknown capabilities continues globally. Let’s look a little deeper into the structure and changes of Omicron compared to delta and Wuhan virus to understand the implications of these mutations.
Three mutations on the furin cleavage site, and about 15 on the receptor binding domain. Let’s review the changes on the cleavage site and their implications.
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References
Mutations: G142D/Δ143-145, Δ211/L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493K, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F
Conserved non-Spike mutations – NSP3 – K38R, V1069I, Δ1265/L1266I, A1892T; NSP4 – T492I; NSP5 – P132H; NSP6 – Δ105-107, A189V; NSP12 – P323L; NSP14 – I42V; E – T9I; M – D3G, Q19E, A63T; N – P13L, Δ31-33, R203K, G204R
SARS-COV AND SARS-COV-2 comparison: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7151553/
SARS-COV-2 genome: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7539923/
https://www.pnas.org/content/117/41/25254
https://ib.bioninja.com.au/standard-level/topic-2-molecular-biology/24-proteins/amino-acids.html
https://www.pnas.org/content/118/47/e2109905118
https://www.frontiersin.org/articles/10.3389/fphar.2020.578382/full
https://www.frontiersin.org/files/Articles/578382/fphar-11-578382-HTML/image_m/fphar-11-578382-g001.jpg
WHO https://www.who.int/news/item/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-cov-2-variant-of-concern
GISAID: https://www.gisaid.org/hcov19-variants/
NY Times. Great article: https://www.nytimes.com/2021/11/26/health/omicron-variant-vaccines.html
About the changes: https://www.worldofmolecules.com/3D/B.1.1.529-variant.html
https://ourworldindata.org/coronavirus/country/south-africa
https://ourworldindata.org/grapher/biweekly-growth-covid-cases?tab=chart&country=~ZAF
https://www.sciencedirect.com/science/article/pii/S2001037021004268
https://nextstrain.org/ncov/gisaid/global?c=emerging_lineage
https://www.gisaid.org/
https://www.gisaid.org/hcov19-variants/
https://www.pnas.org/content/118/43/e2100943118
https://en.wikipedia.org/wiki/Omicron
#drbeen #koolbeens #COVID
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This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
