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0:00 – Introduction
0:33 – Mass Cancer Death
1:53 – Not all Cancers? The Missing Link.
3:01 – Is this applicable to you?
3:44 – The Most Interesting Discovery…
6:24 – Bad News and Good News…
8:03 – How do we Apply This?
9:58 – Main Points
References
[Study 509] Di Tano M, Raucci F, Vernieri C, et al. Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers. Nat Commun. 2020;11:2332. doi:10.1038/s41467-020-16243-3.
Funding/Conflicts: Mixed [Non-Profit: Associazione Italiana per la Ricerca sul Cancro (AIRC) and the Fondazione Umberto Veronesi / Public: Breast Cancer Research Program (US Department of Defense) and the US National Institute on Aging-National Institutes of Health (NIA–NIH)] // Potential Conflicts of Interest [V.D.L. has equity interest in L-Nutra, a company that develops medical food.; A.N. and I.C. are inventors of three patents related to methods for treating cancer using fasting-mimicking diets, which were licensed to L-Nutra; All other authors declare no competing interests.]
[A] Wang F, He MM, Xiao J, et al. A Randomized, Open-Label, Multicenter, Phase 3 Study of High-Dose Vitamin C Plus FOLFOX ± Bevacizumab versus FOLFOX ± Bevacizumab in Unresectable Untreated Metastatic Colorectal Cancer (VITALITY Study). Clin Cancer Res. 2022;28(19):4232-4239. doi:10.1158/1078-0432.CCR-22-0655
[B] Bodeker KL, Smith BJ, Berg DJ, et al. A randomized trial of pharmacological ascorbate, gemcitabine, and nab-paclitaxel for metastatic pancreatic cancer. Redox Biol. 2024;77:103375. doi:10.1016/j.redox.2024.103375
[C] Ligorio F, Lobefaro R, Fucà G, et al. Adding fasting-mimicking diet to first-line carboplatin-based chemotherapy is associated with better overall survival in advanced triple-negative breast cancer patients: A subanalysis of the NCT03340935 trial. Int J Cancer. 2024;154(1):114-123. doi:10.1002/ijc.34701
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