Next steps in the research
The next phase of the project is to validate the findings in larger and more diverse patient groups, including people with plaque psoriasis, to determine whether antigen‑presenting neutrophils can serve as predictive biomarkers or potential drug targets. The researchers also aim to clarify which molecular signals cause neutrophils to change behaviour and how they interact with T cells in early autoimmune inflammation.
This work was made possible through the efforts of Dr. Josefin Lysell , co-last author of the article and a dermatologist at Karolinska University Hospital, whose role in coordinating patient recruitment was instrumental.
The study was conducted in collaboration with Karolinska University Hospital and the LEO Foundation Skin Immunology Research Center at Copenhagen University. Some authors report engagements with pharmaceutical companies; full details are available in the publication.
Publication
” High-dimensional single-cell analyses reveal neutrophil heterogeneity in guttate psoriasis “, Avinash Padhi, Anoop T. Ambikan, Panagiotis Andriopoulos, Indranil Sinha, Mira Akber, Wenning Zheng, Rokeya Sultana Rekha, Laura Palma Medina, Jan-Inge Henter, Mattias Svensson, , Liv Eidsmo, Anna Norrby-Teglund, Ujjwal Neogi, Peter Bergman, Josefin Lysell , Magda Lourda. eBioMedicine, online 19 February 2026, doi: 10.1016/j.ebiom.2026.106172.
