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By now, most of us are familiar with GLP-1s for weight loss.

However, far less is known about a rapidly growing adjacent category: GLP-1 activators. Take Etta Vita’s 2-in-1 Gut Health & Weight Loss Formula, for example. The supplement has become a best-seller on Amazon, with more than 10,000 units purchased in the past month alone.

Marketed as a “natural alternative” to prescription GLP-1 medications, the formula is designed to support key gut–brain pathways that influence hunger hormones and blood sugar regulation. The blend combines clinically-studied ingredients such as hops, inulin, resveratrol, and berberine — which has been shown to support modest weight loss — between 5% and 7% of body weight, according to some research.

Etta Vita’s formula also includes probiotics, polyphenols from pomegranate and grape seed, commonly used to support gut barrier integrity and promote microbial diversity, which could also help with digestive regularity. The supplement is made in America and third-party tested for quality.

So does this GLP-1 Probiotic supplement actually work? That part is still up for debate.

GLP-1 activator supplement Amazon

Reviews are mixed, but some users say it’s helped curb “mindless snacking” and late-night wandering around the kitchen. Others report feeling fuller sooner at meals, and having more willpower when it comes to sugary snacks. Many reviewers have also noted improved digestion and better regularity.

“The boost in willpower against sugary snacks, combined with a noticeable improvement in my digestive comfort, has made a real difference,” one user shared. “It feels less like a harsh suppressant and more like a holistic support system for my body’s natural balance.”

As with all supplements, results can vary. Users should always consult their physician before use.

Find a GLP-1 That Works for You

This article was written by Miska Salemann, New York Post Commerce Writer/Reporter. As a health-forward member of Gen Z, Miska seeks out experts to weigh in on the benefits, safety and designs of both trending and tried-and-true fitness equipment, workout clothing, dietary supplements and more. Taking matters into her own hands, Miska intrepidly tests wellness products, ranging from Bryan Johnson’s Blueprint Longevity Mix to the viral Oura Ring to Jennifer Aniston’s favorite workout platform – often with her adorable toddler by her side. Before joining The Post, Miska covered lifestyle and consumer topics for the U.S. Sun and The Cannon Beach Gazette.