Cracking the Mediterranean diet

An example of a diet that science has helped us understand is the Mediterranean diet. Its effects have been widely documented — its healthy fats and whole, plant-based foods lower our risks for common chronic conditions, particularly heart disease. But what is the mechanism driving these effects? It may well be DMB, or 3,3-dimethyl-1-butanol, found in olive oil, red wine, grapes and raisins, the Cleveland Clinic found, raising the notion it could even be used as an anti-heart disease pharmaceutical. That it is naturally occurring in food goes straight to the heart of the idea that food is medicine — and that if our knowledge can catch up with what we eat, we could offer health interventions that are accessible and delicious.

One easy win FoodAtlas has already found is that we have access to a lot more knowledge about foods than we had previously collected. Valuable nutritional information can make it into journals but get stuck there, never making it out to the public. 

Ilias Tagkopoulos, director of the USDA-NIFA AI Institute for Next Generation Food Systems (AIFS), is applying his extensive computer science expertise to the dark matter of our food system. Photo courtesy USDA-NIFA AI Institute for Next Generation Food Systems (AIFS)

That’s where the artificial intelligence aspect of FoodAtlas comes in. FoodAtlas synthesizes published information from reputable journals and links the studies, the compounds, and the foods containing them neatly together. Nearly half of the food information FoodAtlas was able to gather from scientific journals hadn’t made it into a database anywhere. Networking all available evidence and studies about the foods we eat can be a force multiplier for the research presently being done to expand our understanding of the compounds in food. And it brings us increasingly closer to a world where health and nutrition fully meet — where a doctor can tell you what foods to put in your diet that respond to individual biomarkers or health conditions.

“Knowing what chemicals are in our food and what they do to our bodies is essential for public health,” says Ilias Tagkopoulos, director of the USDA-NIFA AI Institute for Next Generation Food Systems (AIFS). “FoodAtlas has been created with this mission in mind: an AI system that reviews the published literature and databases to map foods, their molecular composition, their health effects, and other parameters that are important for decision support in creating healthier, more sustainable food.”

Swap it Smart

While it’s good to know scientists are making up ground in understanding the compounds in our food, absorbing all that information as a consumer may seem daunting. For all its 90s simplicity, a nutrition label is often too much to take in, let alone figure out how the compounds one label describes interact with those on the label of another food in your grocery cart. Every trip to the grocery store is, fundamentally, a scientific experiment you’re conducting on your own body while trying to finish other errands and make ends meet. Fortunately, UC Davis is developing an app to bring the power of the FoodAtlas and the Periodic Table of Foods Initiative (PTFI) to consumers.

Called “Swap it Smart,” the app will bring AI-powered food composition science into meal formulation. The app categorizes meals across food quality, nutrition, bioactivity, environmental impact, affordability, and flavor while generating recipes aligned with the user’s health and sustainability goals. The ingredient substitutions (“swaps”) suggested will rely on advanced understanding of how food items impact health and the planet. UC Davis already has plans to collaborate with renowned California chefs who will be using the app to make recipes that meet their kitchens’ own nutritional and sustainability goals — expert validation of all that the app, and FoodAtlas, can do.

The app categorizes meals across food quality, nutrition, bioactivity, environmental impact, affordability, and flavor while generating recipes aligned with the user’s health and sustainability goals. The ingredient substitutions (“swaps”) suggested will rely on advanced understanding of how food items impact health and the planet. 

“Swap it Smart is building on the strengths of FoodAtlas and PTFI to create a platform for meal development,” Tagkopoulos says. “It is designed to help nutritionists in schools and chefs in restaurants make delicious meals and dishes that are good for our health and the environment.”

Not every compound scientists discover in our foods will prove consequential — many are likely to simply pass through our bodies with no effect. Some are likely to have beneficial health effects for only some populations — validating the experience many dieters have of success with some combinations of foods but not others. Scratching our heads over what’s included and excluded from a suggested diet may soon be a thing of the past — enjoying tasty and delicious food, decidedly not.