GLP-1 medications have been on the rise for years due to their multifaceted weight-loss benefits. Now, getting your hands on a prescription doesn’t have to be a stressful situation. Instead, you can consult with a handful of online telehealth platforms and even your primary care doctor (or both!). Once you get your medication, don’t forget to add supplements to your daily routine to support your fitness goals and nutritional needs.
Dr. Wiljon Beltre, a board-certified, fellowship-trained bariatric and metabolic surgeon and the founder of Beltre Bariatrics in Orlando, Florida, says to think of GLP-1s as a biological reset button. “They mimic a natural hormone that your gut releases after a meal,” he says. “Their main job is to slow down how fast your stomach empties and tell your brain, ‘we’re full, you can stop thinking about food now.’”
That’s where supplements come in. When your appetite reduces or even disappears, you’re not just eating less food; you’re also getting fewer vitamins and minerals. “Supplements are essential to ensure your hair doesn’t thin, your bones stay strong, and your energy doesn’t drop with the weight,” explains Dr. Beltre.
Best Supplements to Take While on GLP-1s at a Glance
Best Overall: Happy Mammoth Prebiotic Collagen Protein, $70
Best Vitamin B12: Thorne Vitamin B12, $24
Best Digestive Enzymes: Happy V Debloat + Digest, $40 (30-day supply)
Best Vitamin D: Pure Encapsulations Vitamin D3 Liquid, $33
Best Fiber: Sakara Fiber Super Powder, $45
Best Electrolytes: Waterboy Daily Hydration, $40 (was $50)
Best Protein Powder: Promix Whey Protein Powder, $64
Best Multivitamin: Olly Women’s Multi, $16
Do You Need Supplements While on a GLP-1?
This simple answer is, yes, you need supplements while on a GLP-1 medication. Supplements are a supportive addition to your weight loss journey because these drugs often reduce appetite and total food intake, which may increase the risk of nutrient gaps. “Rapid weight loss can also affect body composition and hormone levels, including estrogen, which plays an important role in maintaining vaginal health and supporting protective lactobacillus bacteria,” says registered dietician Lenia Lopez. “Supporting nutrition and microbiome balance with targeted supplements may help the body adapt to metabolic and hormonal changes during weight loss.”
Lama Dalloul, clinical dietitian at Bioniq, also shares that thoughtful supplementation can help maintain overall nutritional balance, support muscle health when protein intake is low, aid energy metabolism and cognitive function, and promote gut health and digestion, especially if gastrointestinal side effects occur. Here are the top supplements you should consider:
Collagen
Vitamin B-12
Protein
Vitamin D
Fiber
Electrolytes
Multi-Vitamins
“I started a micro-dose GLP-1 regimen four months ago, about one year postpartum,” Gina Vaynshteyn, VP, Commerce says. “Even though the dosage was low, I still dealt with fatigue from not getting enough nutrients, which made going to the gym even more of a struggle. Plus, GLP-1s tend to constipate you, so…there was also that. Supplementing my dosage and diet with protein, vitamin B-12, fiber, and electrolytes truly made a world of difference.”
Ahead, shop the best supplements to take while on a GLP-1 medication from Happy Mammoth, Olly, Thorne, and more.
Happy Mammoth is a Flow Space sponsor, however, all products in this article were independently selected by our editors. Please note that if you purchase something by clicking on a link within this story, we may receive a small commission of the sale.
The Best Supplements to Take While on GLP-1s
Happy Mammoth Prebiotic Collagen Protein
Image Credit: Happy Mammoth
Best overall
Happy Mammoth Prebiotic Collagen Protein
Experts recommend supplementing with prebiotics, collagen, and protein, which is why Happy Mammoth’s Prebiotic Collagen Protein mixture is a perfect addition to your GLP-1 journey. It helps to maintain muscle mass, which many users report they struggle with while on the medication. The easily dissolvable powder also helps balance the gut microbiome, which “can assist in reducing cravings and improving satiety,” per the brand. This supplement is free from fillers, soy, gluten, and artificial additives.
Form: Powder
Serving Size: 1 scoop
Flavors: Vanilla
Who is it best for? Anyone looking to maintain muscle mass and relieve constipation. It really is a great all-in-one option.
Thorne Vitamin B12
Image Credit: Thorne
Best Vitamin B12
Thorne Vitamin B12
Dr. Beltre says many GLP-1 users experience fatigue, and B12 supports energy metabolism and nerve function, which can be affected by the meds and reduced food intake. Thorne’s daily B-12 vitamin are a breeze to take, with no pesky aftertaste or side effects. Each capsule contains an active, tissue-ready form of vitamin B12, which supports energy production, heart and eye health, red blood cell formation, and more.
Form: Pill
Serving Size: 1 capsule daily
Flavors: None
Who is it best for? Those with fatigue
Happy V Debloat + Digest
Image Credit: Happy V
Best Digestive Enzymes
Happy V Debloat + Digest
“Digestive enzymes help break down proteins, fats, and carbohydrates into smaller molecules that can be absorbed in the intestine,” Lopez explains. “Because GLP-1 therapies can reduce appetite and overall food intake, maximizing nutrient utilization from smaller meals may be beneficial.” Digestive enzymes may also help support digestion and digestive comfort (such as bloating or fullness).
Happy V’s enzymes promise relief within 30 minutes, support regular bowel movements, and target abdominal pain and gas. The capsules are crafted with science-backed ingredients, including peppermint powder, ginger extract, and sodium. Don’t let the sodium deter you; it helps ease upset stomachs and acid indigestion.
Form: Pill
Serving Size: 2 capsules daily
Flavors: None
Who is it best for? People experiencing bloating and constipation
Pure Encapsulations Vitamin D3 Liquid
Image Credit: Pure Encapsulations
Best Vitamin D
Pure Encapsulations Vitamin D3 Liquid
Dalloul explains that vitamin D combined with calcium is important for bone health, immune function, and overall metabolism, “particularly if intake decreases or weight loss is rapid.” This pick from Pure Encapsulations comes in a liquid form, making it easy to tak espcially for those who don’t prefer pills. The liquid is supported by science to reach the bloodstream more quickly than other forms of vitamin D.
Form: Liquid
Serving Size: 1–7 drops daily with food
Flavors: None
Who is it best for? Those losing muscle mass
Sakara Fiber Super Powder
Image Credit: Sakara
Best FIber
Sakara Fiber Super Powder
“Because meds slow the gut down, things can get ‘stuck’, so I always recommend a daily fiber supplement to keep everything moving as it should,” Beltre says. Sakara’s Fiber Super Powder combines 10 unique prebiotic fruits and vegetables with 10 diverse digestive enzymes to support a thriving microbiome and digestion.
Form: Powder
Serving Size: 1 scoop
Flavors: Hint of pineapple
Who is it best for? Anyone who needs to boost daily fiber intake
Waterboy Daily Hydration
Image Credit: Waterboy
Best Electrolytes
Waterboy Daily Hydration
On Sale 20% off
Dr. Beltre recommends adding an electrolyte to your diet that contains magnesium and potassium. “Rapid weight loss can lead to water loss, and if you feel dizzy or get leg cramps, you’re probably low on electrolytes,” he says. “Magnesium can also help with sleep and muscle recovery.
Snag the Waterboy Daily Hydration packs that are easy to toss in your bag, so never have to worry about dizzy spells and feeling faint. Each pack contains a blend of Himalayan sea salt, potassium citrate, ascorbic acid (vitamin C), magnesium citrate, L-theanine, ginger extract, organic stevia extract, and vitamin B12. The best part? It tastes like a watermelon candy without all the sugar and chemicals.
Form: Powder
Serving Size: 1 pack
Flavors: Watermelon, strawberry lemonade, cucumber citrus, and blue raspberry
Who is it best for? People strugglnig with hydration and dizziness
Promix Whey Protein Powder
Image Credit: Promix
Best Protein Powder
Promix Whey Protein Powder
One of the most important supporting supplements you can add to your routine is protein. When you’re placed on a GLP-1 medication, your provider should discuss your protein goals. “Because you can’t eat big meals, you need to supplement with protein to preserve muscle,” Dr. Beltre explains. “If you lose too much, your metabolism can crash, which will make it next to impossible to keep the weight off later.”
The Promix Whey Protein Powder is simple to add to water, smoothies, coffee, and your other favorite drinks. It’s crafted with grass-fed whey, rich in antioxidants and healthy fats that support muscle mass. It’s free of hormones and added sugars, so you can stay on track with your nutritional goals.
Form: Powder
Serving Size: Two scoops
Flavors: Unflavored, peanut butter, raw chocolate, vanilla, and 4 more
Who is it best for? Those with sensitive digestive needs and people looking to meet protein goals
Olly Women’s Multi
Image Credit: Olly
Best Multivitamin
Olly Women’s Multi
The Olly Women’s Multi helps bridge the gap that comes with rapid weight loss. The formula contains vitamins A, C, D, E, Bs, biotin, and folic acid that help to support immune system health, bone health, and more.
Form: Gummy
Serving Size: 2 gummies a day
Flavors: Blissful berry
Who is it best for? Women of all ages
