Coronavirus (COVID-19) Infection Timeline | Guideline On When To Give Remdesivir, Leronlimab, Tocilizumab
When we look at the timeline of coronavirus (COVID-19) disease progression, we can break COVID-19 into 3 phases:
Infection, Early and Late Phases. And understanding each of them can help us develop risk scoring systems so we know who is more likely to get severe complications and what treatment to start them on. Remember, proactive medicine is “anticipating the viruses next move” and having our defenses up before the attack.
During the infection stage, coronavirus uses the respiratory system as point of entry meaning it enters your mouth, nasal passages and eyes. There is some research going into finding a prophylactic anti-viral to prevent the infection stage but realistically having a balanced immune system that is supported by normal levels of vitamin and essential minerals is key. Preventative measures like wearing masks, social distancing and minimizing contact especially if you are in the high risk category is also advised.
The early phase of the coronavirus infection is the first 7-10 days when most of the symptoms are virally induced. We also know that viral titers are the highest in the earliest phases of infection. It is in this phase where antivirals can be the most effective by inhibiting coronavirus entry and replication. Early phase symptoms range from no symptoms to fever, cough, shortness of breathe, myalgia, loss of taste and smell.
As the infection progresses into the later phases, your body enters a hyperinflammatory state oftentimes referred to as “the cytokine storm”. I believe that most of the mortality of COVID-19 infections can be traced to the cytokine storm and many physicians treating these patients have severely underestimated the impact of cytokines. This is why I think antivirals like Remdesivir are showing little effectiveness compared to immunomodulators like leronlimab and tocilizumab in the later stages of the infection.
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