Previous exposure to viruses has an impact on immunity. SARS-CoV-2 belongs to the betacoronavirus genus of coronaviruses, which includes SARS-CoV-1, MERS-CoV, and two other human coronaviruses (HCoV-OC43 and HCoV-HKU1), which are responsible for some forms of the “common cold.” The betacoronaviruses can induce immune responses against one another. Some research demonstrated that SARS-CoV-2-reactive CD4+ T cells were present in 40 to 60 percent of unexposed people, suggesting cross-reactive T cell recognition between circulating common cold coronaviruses and SARS-CoV-2. In this clip, Dr. Rhonda Patrick discusses what cross-immunity is and how it may be relevant for SARS-CoV-2.
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