Study design and participants Our study is based on data from the ongoing VICTORIA trial (German Clinical Trials Register, EudraCT-No: 2019-000502-30; DRKS00019907, website https://www.bfarm.de/EN/BfArM/Tasks/German-Clinical-Trials-Register/_node.html). Trial design details of the VICTORIA trial have been previously reported [9] (also see Supplementary Methods…