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Defining the Immune System
The immune system is a collection of organs, tissues, cells, and enzymes all united under one goal: protect the body.
Structure of the Immune System
The innate immune response is the non-specific, first response to foreign threats. Immune cells recognize a potential threat, ring the alarm, and the inflammatory response begins.
Read more about the innate immune response.
The acquired immune response is a specific attack on foreign threats. Key players in the acquired immune response include T cells, B cells, and antibodies:
T cells are immune cells with different responsibilities. For example, helper T cells interact with B cells as part of the antibody production process and activate cytotoxic T cells to target the identified pathogen.
B cells are immune cells that can circulate throughout the body, interact with antigen-presenting cells, activate helper T cells, transform into plasma B cells, and mass produce antibodies.
Antibodies are proteins produced by B cells designed specifically to recognize a unique foreign substance, called an antigen.
tcells, B cells, and antibodies also play an important role in creating immunological memory: the ability of the immune system to store information about a specific pathogen in preparation for future attacks by the same pathogen. Immunological memory is an important concept for the creation of vaccines, which fundamentally work by triggering an initial immune response that creates immunological memory without creating disease. So when an individual encounters the “real” pathogen, the immune system is already equipped with the specific machinery to protect the body.
Read more about immunological memory.
A pathogen is a microorganism that can cause disease, such as a bacterium, virus, protozoan, or fungus. An antigen is a piece of a pathogen that can be recognized by antigen-presenting cells of the immune system, an important step in mounting an immune response.
The inflammatory response is mounted by the immune system in response to pathogens first recognized by the innate immune response. Macrophages and other antigen-presenting cells engulf and break down pathogens in a process called phagocytosis. Phagocytosis triggers pro-inflammatory signals and recruits other cells to the infection site.
The goal of the inflammatory response during infection is to prevent the pathogen from spreading to other parts of the body. The inflammatory response involves several physiological mechanisms
nflammation is initiated by pro-inflammatory lipid mediators, cytokines, and chemokines. This process is characterized by the recruitment of immune cells to the infection site to begin targeting pathogens through phagocytosis.
Inflammation resolution is typically a healthy conclusion to the inflammatory process, activated once the immune system has completed whatever task caused it to launch an inflammatory response in the first place. However, various factors can delay resolution, prolonging inflammation and increasing the risk of collateral damage to the body’s own tissues.
Many resolving factors play a role in managing the relationship between initiation and resolution, including:
iimune system needs energy and a variety of nutrients to produce a functional immune response. Specific nutrients impact the physiological mechanisms involved in the inflammatory response, such as the recruitment of immune cells and chemical mediators that communicate between cells in the immune system. Some nutrients can act as antioxidants, which counteract free radical production that occurs as a natural part of the inflammatory response. Balancing levels of reactive oxygen species during the inflammatory response is an important step to make sure unwarranted damage is not done to the body while the immune system fights an infection.
Micronutrients and phytonutrients that serve as antioxidants include:
Vitamin E
Vitamin C
Vitamin D
Zinc
Selenium
Carotenoids
Polyphenols
Resveratrol
Gallic acid.
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