“We uncovered one of the mechanisms by which T cells lose their ability to fight cancer and now we have a target that we can use to design interventions to improve responses to immunotherapy as well as prevent chronic infection,” said Goldrath.
The full list of authors included: Nicole E. Scharping, Xuezhen Ge, Maria Inês Matias, Fulin Jiang, Allison Cafferata, Maximilian Heeg, Alexander Monell, Giovanni Galletti, Kitty P. Cheung, Angelica Rock, Nick Thao, Sydnye L. Shuttleworth, Michael A. Bauer, Kennidy K. Takehara, Amir Ferry, Sara Quon, Brian Koss, Samuel A. Myers, Eric J. Bennett and Ananda W. Goldrath.
The research was performed in the context of the ImmGenT project within the ImmGen consortium (supported by R24072073). National Institutes of Health grants K00CA222711, GM133351, F31AI176705, DP5OD031863, R35GM148339, R21AI178362, R01AI179952, R37AI067545, R01AI072117 and R01AI150282 supported the research.
Declaration of interests: Ferry is a co-founder, CEO and board member of TCura Bioscience. Goldrath is a co-founder of TCura Bioscience, Inc., serves on the scientific advisory board of Foundery Biosciences and is a senior advisor to the Allen Institute for Immunology.