CAR-dendritic cells rewire cardiac immunity for tissue repair

Liu J, Zhang X, Cheng Y, Cao X. Dendritic cell migration in inflammation and immunity. Cell Mol Immunol. 2021;18:2461–71. https://doi.org/10.1038/s41423-021-00726-4.

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Worbs T, Hammerschmidt SI, Förster R. Dendritic cell migration in health and disease. Nat Rev Immunol. 2017;17:30–48. https://doi.org/10.1038/nri1256.

Article 
CAS 
PubMed 

Google Scholar
 

Li X, Li J, Li G, Zhu L, Cheng G, Li H, et al. Engineered immunosuppressive dendritic cells protect against cardiac remodeling. Nature. 2026; https://doi.org/10.1038/s41586-026-10346-5.

Rurik JG, Tombácz I, Yadegari A, Méndez Fernández PO, Shewale SV, Li L, et al. CAR T cells produced in vivo to treat cardiac injury. Science. 2022;375:91–6. https://doi.org/10.1126/science.abm0594.

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Aghajanian H, Kimura T, Rurik JG, Hancock AS, Leibowitz MS, Li L, et al. Targeting cardiac fibrosis with engineered T cells. Nature. 2019;573:430–3. https://doi.org/10.1038/s41586-019-1546-z.

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Du H, You X, Zhang J, Liu S, Zhou Y, Wang Y, et al. CAR macrophages engineered in vivo for attenuating myocardial ischemia‒reperfusion injury. Circ Res. 2025;137:846–59. https://doi.org/10.1161/CIRCRESAHA.125.326716.

Article 
CAS 
PubMed 

Google Scholar
 

Wang J, Du H, Xie W, Bi J, Zhang H, Liu X, et al. CAR-macrophage therapy alleviates myocardial ischemia‒reperfusion injury. Circ Res. 2024;135:1161–74. https://doi.org/10.1161/CIRCRESAHA.124.325212.

Article 
CAS 
PubMed 

Google Scholar
 

Bui TA, Mei H, Sang R, Ortega DG, Deng W. Advancements and challenges in developing in vivo CAR T-cell therapies for cancer treatment. eBioMedicine. 2024;106:105266. https://doi.org/10.1016/j.ebiom.2024.105266.

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Castenmiller C, Keumatio-Doungtsop B-C, van Ree R, de Jong EC, van Kooyk Y. Tolerogenic immunotherapy: targeting DC surface receptors to induce antigen-specific tolerance. Front Immunol. 2021;12:643240. https://doi.org/10.3389/fimmu.2021.643240.

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Busek P, Mateu R, Zubal M, Kotackova L, Sedo A. Targeting fibroblast activation protein in cancer–prospects and caveats. Front Biosci. 2018;23:1933–68. https://doi.org/10.2741/4682.

Article 
CAS 

Google Scholar