Monitoring Accuracy – AMP Vitamin D | CSP

CDC offers a formal program for laboratories to monitor their tests, and another program for researchers to monitor contract laboratories.

CDC CSP enables laboratories and investigators to continuously monitor the accuracy of measurements in patient care and research studies over time.

Using the following process, CDC’s Accuracy-Based Monitoring Program (AMP) helps laboratories monitor the accuracy of their own vitamin D tests over time:

CDC provides participants samples with reference values unknown to the participant.
Participants measure these samples weekly along with their regular patient or study samples.
Participants report the results of their sample measurements to CDC.
Using established statistical assessment procedures, CDC compares participants’ results to the actual concentrations determined with the CDC reference measurement procedures.
CDC provides participants with quarterly assessment reports.

————————————————————————-

CDC AMP – Vitamin D Participant Protocol

CDC Accuracy-Based Monitoring Program Participant Protocol

Apr 5, 2026

—————————————————————-

Using the process below, CDC’s laboratory assessment programs help researchers monitor the accuracy of their contract laboratories’ tests:

CDC provides researchers with “blinded” quality control samples, meaning the quality control samples cannot be differentiated from the study samples. These are vials with serum samples an investigator adds to batches of vials with study samples. These vials are labeled in the same manner as regular study samples. The number of quality control samples used, and the frequency with which they are added to the study samples, can vary depending on the needs and requirements defined by the investigator.
The laboratory measures the samples and reports the results to the investigator.
The investigator compares the reported values with the actual concentrations using CDC’s reference method.